Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Effect of temozolomide combined with radiotherapy on survival and MGMT protein expression in recurrent malignant glioma patients

Feng Yun, Huang Honghui, Gao Jing, Liu Shizhu

Medical College of Jiangsu University, Nanjing City, Jiangsu Province 212000, China;

For correspondence:- Liu Shizhu Email: ds1293@163.com

Accepted: 27 March 2019 Published: 30 April 2019

Citation: Yun F, Honghui H, Jing G, Shizhu L. Effect of temozolomide combined with radiotherapy on survival and MGMT protein expression in recurrent malignant glioma patients. Trop J Pharm Res 2019; 18(4):857-862 doi: 10.4314/tjpr.v18i4.25

© 2019 The authors.
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Abstract

Purpose: To investigate the effect of temozolomide (TMZ) combined with radiotherapy (RT) on O-6-methylguanine-DNA methyltransferase (MGMT) protein and survival of recurrent malignant glioma patients.

Methods: Ninety-two patients with malignant glioma in our hospital from January 2014 to January 2015 were assigned to study and control groups using the random table method. Subjects in the control group received radiotherapy (total dose in the range of 60 – 75 Gy), while those in the study group were given TMZ orally (75 mg/m2) daily in addition to radiotherapy, as well as TMZ at 150 – 200 mg/m2. After treatment, clinical effectiveness was compared for the two groups. Changes in methylation of MGMT gene were determined in the two groups. The patients were followed up for 3 years, and the degrees of survival and recurrence were recorded.

Results: Total effectiveness of clinical treatment was markedly higher in the study group (76.09 %) than in the control group (45.65 %; p < 0.05). One month after radiotherapy, significant decrease in MGMT gene methylation was seen in patients in the study group, relative to control patients (p < 0.05). Patients in the study group had lower median recurrence but higher degree of survival in the 2nd and 3rd years, relative to control patients (p < 0.05).

Conclusion: The combination of temozolomide and radiotherapy is more effective than radiotherapy in the treatment of recurrent malignant glioma. The combined treatment significantly inhibits tumor recurrence in patients, and improves their prognosis and standard of life.

Keywords: Temozolomide, Radiotherapy, Recurrent malignant glioma, Survival rate, MGMT protein